However, the risk factors for CAC initiation in peritoneal dialysis (PD) patients are not known clearly. Binary logistic regression was performed to identify the independent risk factors for CAC progression in the PD patients, and multivariate linear regression was conducted to identify factors associated with hyperphosphatemia. A peripheral form known as calcific uremic arteriolopathy (calciphylaxis) can induce necrotic ulceration and gangrene in affected extremities. The most common cause of this illness is kidney disease. 2011 Sep. 25(5):721-30. Methods. Observational studies have determined hyperphosphatemia to be a cardiovascular risk factor in chronic kidney disease. risk factors (London et al., 2003), the search for non-traditional risk factors has led to increasing evidence of a multitude of factors that contribute to ectopic calcification in CKD. Together they form a unique fingerprint. 1.2 High mortality rate and hyperphosphatemia Inorganic phosphate (phosphate) retention, or hyperphosphatemia… The purpose of this study was to determine risk factors for hyperphosphatemia in ESKD patients treated with peritoneal dialysis (PD). Similar results have been reported with sodium phosphate enemas. Bone and mineral metabolism becomes dysregulated with progression of chronic kidney disease (CKD), and increasing levels of parathyroid hormone serve as an adaptive response to maintain normal phosphorus and calcium levels. Similar results have been reported with sodium phosphate enemas. Background. Hypophosphatemia is an abnormally low level of phosphate in the blood. This information will be used to develop a patient specific phosphate binder application to facilitate patient self-management of serum phosphate. The present study aimed to identify modifiable risk factors for... Hyperphosphatemia as an independent risk factor for coronary artery calcification progression in peritoneal dialysis patients | SpringerLink In advanced CKD, increased dietary phosphorus is associated with hyperphosphatemia. Hyperphosphatemia - The Risk Factor for Adverse Outcome in Maintenance Hemodialysis Patients Hyperphosphatemia is a potent stimulator of vascular and valvular calcifications in hemodialysis patients. The relative risk of overall graft loss and acute rejection among African American renal transplant recipients is attenuated with advancing age. Hyperphosphatemia is an independent risk factor contributing to the increased incidence of aortic and mitral stenosis and other cardiovascular diseases among patients who are dependent on dialysis. Fingerprint Dive into the research topics of 'Lower body weight and female gender: Hyperphosphatemia risk factors after sodium phosphate preparations'. Mechanistic studies have elucidated that hyperphosphatemia is a direct stimulus to vascular calcification, which is one cause of morbid cardiovascular events contributing to the excess mortality of chronic kidney disease. Hyperuricemia and/or hyperphosphatemia were presumed responsible for the development of azotemia in the post-chemotherapy period. Although the multi-collinearity among variables was evaluated, strong correlations (|correlation coefficient: r | > 0.7) were not observed. Phosphate is an electrolyte that helps your body with energy production and nerve function. However, there are other conditions as well that might lead to the phosphate levels going out of balance. Risk factors for the development of hypermagnesemia. Hyperphosphatemia as an independent risk factor for coronary artery calcification progression in peritoneal dialysis patients BMC Nephrology , Jul 2015 Da Shang , Qionghong Xie , Xiaolin Ge , Huanqing Yan , Jing Tian , Dingwei Kuang , Chuan-Ming Hao , Tongying Zhu When there is too much phosphate in the blood, the condition is known as hyperphosphatemia [1]. Hyperphosphatemia and hs-CRP were the independent risk factors for CAC initiation in PD patients. BMC Nephrology. Background: Hyperphosphatemia, serum phosphorus ≥ 4.4 mg/dL, is associated with increased risk for chronic kidney disease and cardiovascular disease. Renal insufficiency or renal failure is one of the common causes of hyperphosphatemia. In addition, compared with patients who had an eGFR of 60-89 mL/min/1.73 m2, those with an eGFR below 29 had a 2.3 times increased risk of hyperphosphatemia. PHILADELPHIA—Hyperphosphatemia is an independent risk factor for coronary artery calcification (CAC) progression in patients undergoing peritoneal dialysis (PD), according to a … Multivariate analysis revealed that hyperphosphatemia and hs-CRP were the independent risk factors for CAC initiation after adjustments. However, the association be-tween hyperphosphatemia and CAC progression re-mains controversial in ESRD patients on PD [10, 11, 13, 14, 25]. Coronary artery calcification (CAC) contributes to high risk of cardiocerebrovascular diseases in dialysis patients. Previous studies have shown a weak association between dietary phosphorus … These results suggested potential clinical strategies to prevent the initiation of CAC in PD patients. Hyperphosphatemia and hs-CRP as Independent Risk Factors for CAC Initiation The two groups were weakly different in BMI ( p = 0.087), uric acid (UA) ( p = 0.087), Homa-IR ( p = 0.105), and residual CCR ( p = 0.056), while they were similar in hemoglobin, AKP, ferritin, cholesterol, LDL, iPTH, and adjusted calcium. Conclusions. Lower body weight and female gender: Hyperphosphatemia risk factors after sodium phosphate preparations Parakkal Deepak and Eli D Ehrenpreis Parakkal Deepak, Department of Gastroenterology, NorthShore University Hospital, 2650 Ridge Ave Evanston, IL 60201-1718, United States With regard to sudden death, two previous observational studies suggested an association between serum phosphate levels and the risk of sudden death in patients on hemodialysis[ 9 , 10 ]. Hyperphosphataemia Is Associated with the Diabetes-related Cardiovascular Risk Factors Two patients were dialyzed for renal failure due to hyperuricemia and one for renal failure due to hyperphosphatemia which developed shortly after starting chemotherapy. Indeed, patients with hyperphosphatemia on hemodialysis have an elevated risk of lethal forms of CVD, such as myocardial infarction and stroke [7,8]. Hyperphosphatemia can weaken bones and cause damage to veins, tissues, and organs in the body. For hyperphosphatemia, most studies had proved that hyperphosphatemia was an independent risk factor for mortality or morbidity [1,7,11,14,15,[20][21] [22] [23][24][25][26]. Marked elevation of phosphorus is due to these factors: Renal insufficiency – acute or chronic. Hyperphosphatemia has been associated with increases in vessel wall thickness and arterial stiffness [24]. Linear regression was performed to analyze associations between the average serum phosphate level and other factors. Increased age, abnormal bowel motility, and decreased kidney function are all risk factors for persistent and significant hyperphosphatemia. Increased age, abnormal bowel motility, and decreased kidney function are all risk factors for persistent and significant hyperphosphatemia. This information will be used to develop a patient specific phosphate binder application to facilitate patient self-management of serum phosphate. Causes of hyperphosphatemia (S) Syndrome of Tumor Lysis is a metabolic problem that mainly occurs with treatment of cancer with chemotherapy. (2013) Wojcicki. The risk factors for hyperphosphatemia. Hyperphosphatemia: a novel risk factor for mortality in chronic kidney disease Cardiovascular (CV) mortality in chronic kidney disease (CKD) associate with traditional risk factors (1) including dyslipidaemia, diabetes, smoking and left ventricular mass hypertrophy. Slowing kidney damage is the best way to reduce the risk of hyperphosphatemia [2]. The purpose of this study was to determine risk factors for hyperphosphatemia in ESKD patients treated with peritoneal dialysis (PD). kidney-specific risk factors, such as enhanced activity of the renin–angiotensin system, sympathetic overactivity, endothelial dysfunction (related to the accumulation of asymmetric dimethylarginine, chronic inflammatory state, and oxidative stress), hyperphosphatemia, and CKD … In end-stage renal disease, this response becomes maladaptive and high levels of phosphorus may occur. Hyperphosphatemia has been associated with adverse outcomes in patients with end stage kidney disease (ESKD). [Medline] . Hyperphosphatemia in adults is defined as a serum phosphorus level greater than 5.0 mg/dl. Clin Transplant . The prevalence of hyperphosphatemia in the general population and in persons with renal failure is similar throughout the world.Hyperphosphatemia is a well recognized risk factor for cardiovascular mortality in dialysis patients. 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